Pediatric refractory status epilepticus: Predictors of in-hospital outcomes from a Chinese tertiary center.
In-hospital mortality occurred in about 15% of pediatric refractory status epilepticus cases.
Pediatric refractory status epilepticus: Predictors of in-hospital outcomes from a Chinese tertiary center.
Refractory status epilepticus (refractory status epilepticus) is a life-threatening neurological emergency in children.
This study characterized treatment patterns, in-hospital outcomes, and predictors of clinical outcomes within a resource-constrained regional referral network.
We performed a single-center retrospective cohort study of pediatric patients admitted with refractory status epilepticus between March 2018 and March 2026.
about 1 in 7 children with refractory status epilepticus died in hospital
Demographic, clinical, treatment, and outcome data were systematically collected.
All patients received benzodiazepines as first-line therapy, but only 67 episodes received guideline-recommended dosing.
Favorable discharge outcomes were observed in 50.7% of patients and were independently associated with prior epilepsy (odds ratio [OR], 2.379; 95% confidence interval [CI], 1.07-5.27), adequate first-line benzodiazepine dosing (OR, 2.104; 95% CI, 1.02-4.33), and shorter duration of status epilepticus (OR, 1.991; 95% CI, 1.53-2.58).
These findings suggest that key prognostic determinants of pediatric refractory status epilepticus are consistent across different resource settings.