Severe abdominal adverse events following open abdomen: a multicenter retrospective observational study.

Cohort studyInternational journal of surgery (London, England)· Feb 2026

Severe abdominal adverse events following open abdomen: a multicenter retrospective observational study.

Ryo Yamamoto, Masayuki Shimizu, Hiroharu Shinozaki … Junichi Sasaki

Read paper

Trauma & Acute Care SurgeryCohort study

Low fluid resuscitation before open abdomen surgery linked to more severe abdominal complications

Severe abdominal adverse events following open abdomen: a multicenter retrospective observational study.

Ryo Yamamoto … Junichi Sasaki

International journal of surgery (London, England) · Feb 2026

Background

Open abdomen (open abdomen) is a surgical strategy used for conditions such as intra-abdominal organ injury, abdominal compartment syndrome, and abdominal sepsis.

Purpose

This study aimed to identify practical predictors of severe abdominal adverse events in patients treated with open abdomen.

Methods

This post hoc analysis used data from the nationwide, multicenter retrospective OPTITAC study, which included adult patients (≥18 years) who had undergone laparotomy requiring open abdomen between 2010 and 2022 across 12 hospitals.

n = 302 patients

Results

less than 2 L fluid before surgery raised odds of severe complications

OR 2.39 (95% CI 1.60 to 3.57)

CI excludes the null - significant

More results

Of the 302 patients included in this study, 74 (24.5%) experienced severe abdominal adverse events after open abdomen.

In contrast, greater preoperative fluid volume was associated with a decreased incidence of severe abdominal adverse events [OR: 0.73 (0.59-0.91) per 1 l increase].

More results

In addition, a fluid balance <2 l within 24 hours after surgery was associated with abdominal adverse events in patients with nonelevated postoperative serum lactate levels.

“

Conclusion · 1 of 2

Low preoperative fluid volume and high BMI were associated with an increased incidence of severe abdominal adverse events in patients undergoing open abdomen.

Conclusion · 2 of 2

These findings underscore the importance of fluid resuscitation before surgery in patients undergoing open abdomen.

Severe abdominal adverse events following open abdomen: a multicenter retrospective observational study.

Severe abdominal adverse events following open abdomen: a multicenter retrospective observational study.

Related papers