Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a…

Cohort studyNature communications· Jun 2026

Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.

Lindsey R Hall, Emily E Benedict, Fabia Edathadathil … Sumanth Gandra

Surgical Critical CareCohort studyQ1IF 16.6

Over a third of ICU patients acquired carbapenem-resistant Enterobacterales after admission

Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.

Lindsey R Hall … Sumanth Gandra

Nature communications · Jun 2026

Background

Carbapenemase-producing carbapenem-resistant Enterobacterales (Carbapenemase-producing carbapenem-resistant Enterobacterales) transmission studies incorporating clinical and genomic data from hospitals in India are lacking.

Methods

We prospectively enrolled surgical intensive care unit (surgical intensive care unit) patients in a tertiary-care hospital in India (July 29 to November 30, 2023) and collected peri-rectal swabs at surgical intensive care unit admission, surgical intensive care unit discharge, and hospital discharge, alongside surgical intensive care unit environmental sampling.

n = 103

36.5%

Results

36.5%

over a third of initially negative ICU patients newly acquired Carbapenemase-producing carbapenem-resistant Enterobacterales

n = 103

More results

Twenty-seven percent of participants were Carbapenemase-producing carbapenem-resistant Enterobacterales-colonized on surgical intensive care unit admission, with risk factors of previous hospitalization and exposure to ≥2 antimicrobials.

“

Conclusion

Highly similar E. coli and K. pneumoniae clusters suggest hospital transmission, although the sample size limited network inference.

Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.

Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.

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