Refeeding Hypophosphatemia Among Critically Ill Surgical Patients: A Prospective Analysis of Incidence, Risk…

ObservationalNutrients· May 2026

Refeeding Hypophosphatemia Among Critically Ill Surgical Patients: A Prospective Analysis of Incidence, Risk Factors, and Clinical Outcomes.

Tutkun Talih, Gamze Talih, Umut S Eser … Kürşat Gündoğan

Surgical Critical CareObservationalQ1IF 6.0

76% of critically ill surgical ICU patients developed refeeding hypophosphatemia

Refeeding Hypophosphatemia Among Critically Ill Surgical Patients: A Prospective Analysis of Incidence, Risk Factors, and Clinical Outcomes.

Tutkun Talih … Kürşat Gündoğan

Nutrients · May 2026

Purpose

This study aimed to determine the incidence of refeeding hypophosphatemia (refeeding hypophosphatemia) in critically ill surgical patients admitted to the surgical intensive care unit, to identify associated risk factors, and to evaluate its impact on clinical outcomes.

Methods

This prospective observational study included 135 patients admitted to the general surgery ICU for ≥48 h, with 109 included in the final analysis.

n = 135 patients

Results

most patients developed low phosphate from refeeding, over half severely

11%

Mild RH

11%

Moderate RH

54%

Severe RH

More results

In multivariable analysis, lower albumin, decreased HCO 3 and higher WBC were associated with refeeding hypophosphatemia.

Reoperation (18%) and shock (14%) were the most common complications.

Mechanical ventilation was required in 62% of patients.

Median ICU stay was 8 days, and ICU mortality was 22%.

“

Conclusion · 1 of 2

Refeeding hypophosphatemia is highly prevalent among critically ill surgical patients, with more than half of affected patients developing severe hypophosphatemia.

Conclusion · 2 of 2

Higher disease severity, hypoalbuminemia, and vasopressor use were identified as significant risk factors for refeeding hypophosphatemia.

Refeeding Hypophosphatemia Among Critically Ill Surgical Patients: A Prospective Analysis of Incidence, Risk Factors, and Clinical Outcomes.

Refeeding Hypophosphatemia Among Critically Ill Surgical Patients: A Prospective Analysis of Incidence, Risk Factors, and Clinical Outcomes.

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