Efficacy of phloroglucinol in pediatric acute intussusception and development of a predictive model for treatment failure: a retrospective cohort study.
Nomogram predicts phloroglucinol treatment failure in pediatric intussusception with high accuracy.
Efficacy of phloroglucinol in pediatric acute intussusception and development of a predictive model for treatment failure: a retrospective cohort study.
Acute intussusception is a common abdominal emergency in children.
This study aimed to evaluate the efficacy of phloroglucinol compared with air enema for pediatric acute intussusception and to develop and validate a predictive model for phloroglucinol treatment failure, aiding clinicians in early identification of high-risk children for timely management adjustment and prevention of severe complications.
We retrospectively analyzed clinical data from 1149 children with acute intussusception admitted to our hospital between January 2014 and December 2023.
(2) Multivariate logistic regression analysis identified duration of symptoms, vomiting, and intussusception depth as independent risk factors for phloroglucinol treatment failure (all P < 0.05).
Calibration curves demonstrated excellent agreement between predicted probabilities and observed outcomes.
Decision curve analysis indicated a significant clinical net benefit of the model.
Phloroglucinol appears to be an effective treatment option for pediatric acute intussusception.
The developed nomogram, based on duration of symptoms, vomiting, and intussusception depth, exhibits robust predictive performance and may serve as a convenient and reliable tool for the early identification of children at high risk for phloroglucinol treatment failure, facilitating timely clinical decision-making.