Disease Severity of Respiratory Syncytial Virus Infection in Hospitalized Children.
Respiratory syncytial virus-rhinovirus coinfection not linked to more severe disease than respiratory syncytial virus alone
Disease Severity of Respiratory Syncytial Virus Infection in Hospitalized Children.
Respiratory syncytial virus (respiratory syncytial virus) is a leading cause of hospitalization for acute respiratory tract infection (acute respiratory tract infection) in young children.
Were classified as having respiratory syncytial virus monoinfection, respiratory syncytial virus-rhinovirus coinfection, or respiratory syncytial virus-non-rhinovirus coinfection.
coinfection did not raise the risk of severe disease
Children with respiratory syncytial virus-rhinovirus coinfection were older and had shorter hospital stays.
Severe disease occurred in 80.5% of respiratory syncytial virus monoinfections, 70.8% of respiratory syncytial virus-rhinovirus coinfections, and 75.0% of respiratory syncytial virus-non-rhinovirus coinfections.
Respiratory syncytial virus-rhinovirus and respiratory syncytial virus-non-rhinovirus coinfections were not associated with greater disease severity compared with respiratory syncytial virus monoinfection in hospitalized children.
These findings support pathogen-specific interpretation of multiplex diagnostic results and inform clinical risk stratification in the era of expanding respiratory syncytial virus prevention strategies.