Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in…

StudyHead and neck pathology· May 2026

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

Ricardo Anderson de Oliveira Vasconcelos, Isaac Santos Araújo, Luiz Miguel Ferreira … Ciro Dantas Soares

Head & Neck & Endocrine PathologyStudyDiagnosisQ1IF 2.0

MAML2 rearrangement found in all Warthin-like mucoepidermoid carcinoma cases tested

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

Ricardo Anderson de Oliveira Vasconcelos … Ciro Dantas Soares

Head and neck pathology · May 2026 · Q1 in Pathology

Background

Warthin-like mucoepidermoid carcinoma (warthin-like mucoepidermoid carcinoma) is a low-grade variant of mucoepidermoid carcinoma (mucoepidermoid carcinoma), characterized by a multicystic growth pattern and dense lymphoid stroma, histologically mimicking Warthin tumor (warthin tumor).

Purpose

We aimed to provide a comprehensive clinical, histopathologic, and molecular analysis of new warthin-like mucoepidermoid carcinoma cases.

Methods

Fourteen warthin-like mucoepidermoid carcinoma cases from Brazil, Guatemala, and Mexico were analyzed.

n = 14 cases

100%

Results

100%

MAML2 rearrangement confirmed in every case tested

n = 14 cases

More results

Few cases have been reported, limiting understanding of this variant.

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Conclusion · 1 of 2

This study provides new insights into the clinicopathological and molecular features of warthin-like mucoepidermoid carcinoma, confirming its typical presentation (parotid gland, middle-aged females), low-grade behavior, and favorable prognosis after surgical excision.

Conclusion · 2 of 2

Detection of MAML2 rearrangement is a valuable diagnostic tool for distinguishing warthin-like mucoepidermoid carcinoma from warthin tumor.

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

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