Clinicopathological characterization and prognostic factors of H3 K27M-altered diffuse midline gliomas: A real-world cohort study.

The 5-year survival rate for diffuse midline glioma remains close to zero.

Kaplan-Meier analysis indicated that the prognosis of adult patients was better than that of the pediatric cohort (P = 0.006).

Multivariable Cox regression identified male sex, spinal cord tumor location, and a Ki-67 index of ≤ 10% as independent favorable prognostic factors.

Also, meta-analysis indicated that the prognosis of adult patients was better than that of the pediatric cohort (P = 0.002), patients with brainstem tumors had a worse prognosis compared to those with tumors in other locations (P = 0.003).