Significance of placental pathology and CMV PCR in assessing clinical outcomes of congenital CMV infection.
Placental intrauterine growth restriction more common when cytomegalovirus-typical histology or PCR-positive cytomegalovirus present
Significance of placental pathology and CMV PCR in assessing clinical outcomes of congenital CMV infection.
Congenital cytomegalovirus (cytomegalovirus) infection is one of the most common congenital infections with adverse outcomes such as intrauterine growth restriction (intrauterine growth restriction), hearing loss, and neurologic deficits.
The aim of this study was to investigate the significance of histopathologic features and cytomegalovirus PCR results of placentas with clinical manifestation of congenital cytomegalovirus infections.
We retrospectively collected the placentas of 27 newborns with congenital cytomegalovirus infections from January 2009 to December 2020.
Intrauterine growth restriction occurred in most cytomegalovirus-positive placentas, never without cytomegalovirus involvement
Cytomegalovirus was identified in 12 (44.4 %) cases by immunohistochemistry and 19 (70.4 %) cases by PCR.
PCR detected cytomegalovirus in 2 (22.2 %) out of 9 cases without cytomegalovirus-typical histology.
1/8 (12.5 %), P = 0.043).
6/12 (50 %), P = 0.044).
The associations of placental pathologic findings and cytomegalovirus PCR results with clinical outcomes of congenital cytomegalovirus infection suggest that a comprehensive examination of the placenta is important in congenital cytomegalovirus infection.