ERG expression in BPH vs prostatic adenocarcinoma and its correlation with Gleason grade group.

Cross-sectionalJPMA. The Journal of the Pakistan Medical Association· Feb 2026

ERG expression in BPH vs prostatic adenocarcinoma and its correlation with Gleason grade group.

Mubina Qayyum, Summayya Shawana, Beenish Hussain Nomani … Hafsa Qayyum

Read paper

Genitourinary PathologyCross-sectionalQ3IF 0.6

ERG staining positive in most prostate cancers, absent in benign hyperplasia.

ERG expression in BPH vs prostatic adenocarcinoma and its correlation with Gleason grade group.

Mubina Qayyum … Hafsa Qayyum

JPMA. The Journal of the Pakistan Medical Association · Feb 2026 · Q3 in General Medicine

Purpose

To evaluate immunohistochemical expression of erythroblast transformation-specific-related gene in prostate carcinoma and benign prostate hyperplasia, and its association with Gleason grade groups.

Methods

The retrospective, comparative, cross-sectional study was conducted from January to December 2022 at the Department of Histopathology, Pakistan Navy Ship Shifa Hospital, Karachi, and comprised prostate samples from January 2019 to January 2020.

n = 60 cases

Results

60.6%

60.6% of prostate cancer samples stained ERG-positive; all benign hyperplasia samples were negative.

n = 60 cases

More results

Weak positive staining was observed in 3(9.1%), and moderate in 3(9.1%) cases.

Strongly positive ERG expression was found in 14(42.4%) patients.

The erythroblast transformation-specific-related gene was equally expressed in low and high Gleason grade groups of prostate carcinoma (p>0.05).

More results

All 27(100%) cases of benign prostate hyperplasia showed negative immunohistochemical expression for erythroblast transformation-specific-related gene.

“

Conclusion

The erythroblast transformation-specific-related gene expression was found to be associated with prostate carcinoma compared to benign prostate hyperplasia cases, and could be used as a diagnostic tool for distinguishing between the two.

ERG expression in BPH vs prostatic adenocarcinoma and its correlation with Gleason grade group.

ERG expression in BPH vs prostatic adenocarcinoma and its correlation with Gleason grade group.

Related papers