Clinical utility of serum Mac-2 binding protein glycosylation isomer as a noninvasive marker for liver fibrosis in biliary atresia.

M2BPGi increased progressively with fibrosis stage and outperformed all comparators.

The optimal Youden-derived cutoff index (cutoff index) of 3.02 showed strong performance (stage ≥F3: 87.8% sensitivity and 96.5% specificity; F4: 97.6% sensitivity and 93.6% specificity).

A rule-out cutoff index threshold of 0.81 achieved 100% sensitivity and a negative predictive value for stage ≥F3.