Familial Co-Aggregation of Neurodevelopmental Conditions and Childhood-Onset Type 1 Diabetes. | ScholarDeck

Paper

Familial Co-Aggregation of Neurodevelopmental Conditions and Childhood-Onset Type 1 Diabetes.

New research · Pediatrics

Acta paediatrica (Oslo, Norway : 1992) · 2w

Cohort studyActa paediatrica (Oslo, Norway : 1992)· Aug 2026

Familial Co-Aggregation of Neurodevelopmental Conditions and Childhood-Onset Type 1 Diabetes.

Shengxin Liu, Gisele Magarotto Machado, Irzam Hardiansyah … Agnieszka Butwicka

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Pediatric Endocrinology & GrowthCohort study

Childhood-onset type 1 diabetes linked to higher odds of neurodevelopmental diagnoses

Familial Co-Aggregation of Neurodevelopmental Conditions and Childhood-Onset Type 1 Diabetes.

Shengxin Liu … Agnieszka Butwicka

Acta paediatrica (Oslo, Norway · Aug 2026

Purpose

Childhood-onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (neurodevelopmental conditions).

Methods

Using Swedish registers, we identified 4 066 634 individuals born 1973-2015 and linked them to siblings and cousins; 23 212 (0.57%) had T1D before 18 years.

n = 634 individuals

Results

children with T1D had higher odds of a neurodevelopmental diagnosis

OR by subgroup · 95% CI

More results

Full siblings also had higher odds (OR 1.12; 95% CI 1.06-1.18), whereas no significant associations were observed among other relatives.

Cross-trait phenotypic correlations were small (0.06-0.08).

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Conclusion · 1 of 3

Individuals with childhood-onset T1D and their full siblings had higher odds of recorded neurodevelopmental conditions diagnoses.

Conclusion · 2 of 3

Shared familial factors appeared to contribute only modestly, while differential ascertainment and family-level consequences of T1D may also play a role.

Conclusion · 3 of 3

These findings support access to neurodevelopmental expertise in paediatric diabetes services.

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