Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a…

Cohort studyIndian journal of pathology & microbiology· Jan 2026

Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.

Mukund N Sable, J N Aparnna, Suvendu Purkait

Surgical PathologyCohort studyQ3IF 0.6

EWSR1 gene rearrangement found in most Ewing family tumors, FUS in a minority.

Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.

Mukund N Sable … Suvendu Purkait

Indian journal of pathology & microbiology · Jan 2026 · Q3 in Pathology

Background

Ewing family of tumors (ewing family of tumors) encompass a group of small blue round cell tumors, including Ewing sarcoma (ewing sarcoma) and EWSR1-negative undifferentiated small round cell sarcoma.

Methods

A retrospective analysis of 47 cases diagnosed as Ewing sarcoma and undifferentiated small blue round cell tumors over a period of 3 years was done.

n = 47 cases

Results

EWSR1 rearrangement was the dominant driver, FUS explained only a few cases

45cases

EWSR1 rearrangement

2cases

FUS rearrangement

More results

The mean age of presentation was 21.7 years.

Classical morphology was noted in 64% of the cases.

All cases were CD99 positive, with variable patterns of expression.

DUX4 and CCNB3 IHC were negative in all cases.

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Conclusion · 1 of 2

In EFTs, EWSR1 gene rearrangement is most common, followed by FUS gene rearrangement. CD99 immunohistochemistry with additional molecular analysis is essential for further classification of EFTs.

Conclusion · 2 of 2

A detailed diagnostic algorithm including histology, IHC, and molecular studies is imperative for accurate subcategorization of EFTs.

Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.

Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.

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