PSMA PET Imaging for Prostate Cancer Recurrence After Minimally Invasive Focal Therapy: A Single-Center…

Cohort studyJournal of nuclear medicine : official publication, Society of Nuclear Medicine· Aug 2026

PSMA PET Imaging for Prostate Cancer Recurrence After Minimally Invasive Focal Therapy: A Single-Center Retrospective Study.

Mahbod Jafarvand, Andrea Farolfi, Riccardo Mei … Jeremie Calais

Nuclear & Molecular ImagingCohort studyQ1IF 6.5

Prostate-specific membrane antigen PET/CT detected recurrence with higher sensitivity than MRI after focal therapy

PSMA PET Imaging for Prostate Cancer Recurrence After Minimally Invasive Focal Therapy: A Single-Center Retrospective Study.

Mahbod Jafarvand … Jeremie Calais

Journal of nuclear medicine · Aug 2026 · Q1 in Radiology

Background

Prostate-specific membrane antigen (prostate-specific membrane antigen)-targeted PET/CT (prostate-specific membrane antigen PET/CT) has become the first-line imaging modality used for staging and restaging prostate cancer.

Purpose

This study evaluated prostate-specific membrane antigen PET/CT for detecting and localizing recurrence after focal therapy.

Methods

This retrospective single-center study included patients with prior focal therapy for prostate cancer who underwent 68 Ga-PSMA-11 PET/CT for suspected recurrence between 2016 and 2023 without intervening treatment.

n = 112 patients

Results

PET found recurrence more often than MRI

PET sensitivity

85%

MRI sensitivity

82%

More results

Prostate-specific membrane antigen PET/CT showed 82% positivity for intraprostatic recurrence, 15% for pelvic nodes, and 9% for distant metastases.

Interreader agreement was moderate (κ = 0.4; 95% CI, 0.32-0.54).

82% for MRI.

All cases with an SUV max of 10 or greater had an ISUP grade group of 3 or greater.

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Conclusion

Prostate-specific membrane antigen PET/CT effectively localizes prostate cancer recurrence after focal therapy, outperforming MRI on sensitivity.

PSMA PET Imaging for Prostate Cancer Recurrence After Minimally Invasive Focal Therapy: A Single-Center Retrospective Study.

PSMA PET Imaging for Prostate Cancer Recurrence After Minimally Invasive Focal Therapy: A Single-Center Retrospective Study.

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