OPPORTUNISTIC POPLITEAL ARTERY ASSESSMENT ON KNEE MRI AND MEDIAL TIBIAL STRUCTURAL DAMAGE IN OSTEOARTHRITIS…

Cohort studyOsteoarthritis imaging· 2026

OPPORTUNISTIC POPLITEAL ARTERY ASSESSMENT ON KNEE MRI AND MEDIAL TIBIAL STRUCTURAL DAMAGE IN OSTEOARTHRITIS: FNIH DATA.

P Mirghaderi, N Eshraghi, F Pishgar … M Chalian

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Musculoskeletal ImagingCohort study

Higher popliteal artery wall eccentricity linked to worse baseline medial tibial cartilage loss

OPPORTUNISTIC POPLITEAL ARTERY ASSESSMENT ON KNEE MRI AND MEDIAL TIBIAL STRUCTURAL DAMAGE IN OSTEOARTHRITIS: FNIH DATA.

P Mirghaderi … M Chalian

Osteoarthritis imaging · 2026

Background

Vascular pathology has been proposed as a contributor to knee OA structural damage, but evidence remains inconsistent.

Purpose

To evaluate whether baseline MRI-derived popliteal artery wall biomarkers are associated with baseline severity and 24-month worsening of medial tibial cartilage loss and bone marrow lesions (bone marrow lesions) in the FNIH Osteoarthritis Biomarkers Consortium.

Methods

This analysis included 600 FNIH participants, with one knee per participant.

n = 600 participants

Results

more eccentric artery walls tracked with worse baseline medial tibial cartilage loss

β 0.44 (95% CI 0.09 to 0.79)

CI excludes the null - significant

More results

Mean age was 61.6 ± 8.9 years, mean BMI was 30.7 ± 4.8 kg/m², and 353/600 participants (58.8%) were female.

Popliteal artery wall biomarkers were not associated with 24-month worsening of cartilage loss or bone marrow lesions.

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Conclusion · 1 of 2

Popliteal artery wall eccentricity on knee MRI was associated with greater baseline medial tibial cartilage loss and bone marrow lesions severity, but not with 24-month worsening.

Conclusion · 2 of 2

Opportunistic vascular assessment on knee MRI may help characterize vascular-related baseline structural disease burden in knee OA.

OPPORTUNISTIC POPLITEAL ARTERY ASSESSMENT ON KNEE MRI AND MEDIAL TIBIAL STRUCTURAL DAMAGE IN OSTEOARTHRITIS: FNIH DATA.

OPPORTUNISTIC POPLITEAL ARTERY ASSESSMENT ON KNEE MRI AND MEDIAL TIBIAL STRUCTURAL DAMAGE IN OSTEOARTHRITIS: FNIH DATA.

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