Digital quantification of PRAME for distinguishing melanoma from nevi compared to manual assessment.

We found our novel digital quantitative method was at least as precise at classifying lesions as benign or malignant as the current manual qualitative assessment.

Our method has the advantages of being operator-independent, objective, and replicable. Furthermore, our method can easily be implemented in an already digitalized pathology department.

Given the small cohort size, more studies are to be done to validate our findings.