Dose-response relationship between growth hormone treatment and the development of scoliosis in children…

Cross-sectionalAnnals of medicine· Dec 2026

Dose-response relationship between growth hormone treatment and the development of scoliosis in children with short stature.

Pan Ren, Yuxi Su, Wenquan Cai

Pediatric Endocrinology & GrowthCross-sectionalQ1IF 5.0

Growth hormone therapy linked to over twice the risk of new-onset scoliosis in short-stature children

Dose-response relationship between growth hormone treatment and the development of scoliosis in children with short stature.

Pan Ren … Wenquan Cai

Annals of medicine · Dec 2026 · Q1 in General Medicine

Purpose

We sought to investigate whether growth hormone (growth hormone) treatment increases the risk of scoliosis in children with short stature and analyse a dose-response relationship.

Methods

The cross-sectional study included 1160 children with short stature (355 and 805 in the growth hormone-exposed and non-exposed groups, respectively).

n = 1160 children

Results

Growth hormone-treated children had over 2.7 times the risk of new-onset scoliosis

HR 2.73 (95% CI 1.33 to 5.61)

null 1

1.33

5.61

CI excludes the null - significant

More results

The total growth hormone dose was positively correlated with scoliosis risk, and there was a dose-response relationship between the total growth hormone dose and the risk (HR=1.002, 95%CI: 1.001-1.003, p<0.001).

A dose-response relationship was confirmed, with the predicted probability of scoliosis increasing continuously with cumulative growth hormone dose.

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Conclusion · 1 of 2

Growth hormone therapy is an independent risk factor for scoliosis in children with short stature, with a significant dose-response relationship.

Conclusion · 2 of 2

The cumulative growth hormone dose can be used as a preliminary reference indicator for risk stratification and personalized monitoring.

Dose-response relationship between growth hormone treatment and the development of scoliosis in children with short stature.

Dose-response relationship between growth hormone treatment and the development of scoliosis in children with short stature.

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