Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort…

StudyJournal of magnetic resonance imaging : JMRI· Jul 2026

Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort and Image Quality in Liver MRI: A Prospective, Double-Blind, Self-Controlled Before-and-After Study.

Kanghua Feng, Haifeng Xu, Minghao Li … Yi Huang

Abdominal & Body ImagingStudyQ1IF 3.1

Pre-warming contrast to 37°C nearly doubled excellent arterial phase image quality

Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort and Image Quality in Liver MRI: A Prospective, Double-Blind, Self-Controlled Before-and-After Study.

Kanghua Feng … Yi Huang

Journal of magnetic resonance imaging · Jul 2026 · Q1 in Radiology

Background

Compromised patient comfort and suboptimal arterial phase (arterial phase) image quality remain unresolved challenges in Gd-EOB-DTPA-enhanced liver MRI.

Purpose

To evaluate the effects of pre-warmed (37°C) Gd-EOB-DTPA contrast medium on patient comfort and image quality in liver MRI.

Methods

STUDY TYPE: Prospective, single-center, double-blind, self-controlled before-and-after study.

50.0%

Results

50.0%

vs. 0.7%

excellent arterial phase images became far more common with pre-warmed contrast

More results

For the hepatobiliary phase, contrast-to-noise ratio (contrast-to-noise ratio) and liver-to-spleen contrast ratio (LSC) changes were not significant (p = 0.067, p = 0.079, respectively).

In vitro, Gd-EOB-DTPA maintained stable chemical properties and its viscosity, shear stress, and torque decreased.

More results

Renal function showed no differences (urea p = 0.933, creatinine p = 0.249, endogenous clearance p = 0.206).

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Conclusion

Pre-warming Gd-EOB-DTPA to 37°C improves patient comfort, reduces adverse sensations, optimizes arterial phase image quality, and maintains hepatobiliary phase image quality. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 3.

Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort and Image Quality in Liver MRI: A Prospective, Double-Blind, Self-Controlled Before-and-After Study.

Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort and Image Quality in Liver MRI: A Prospective, Double-Blind, Self-Controlled Before-and-After Study.

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