Default-threshold operating-point validation of a commercial chest radiograph AI system for selected CT-anchored thoracic findings: a bi-national multicenter retrospective study.

For potentially dynamic findings, the allowable CT-CXR interval was restricted to ≤ 2 days.

Diagnostic performance was summarized using prevalence, sensitivity, specificity, positive predictive value, negative predictive value, and false-positive burden with 95% confidence intervals.

Reference-positive prevalence ranged from 2.2% for pneumothorax to 21.0% for pleural effusion.

PPV ranged from 43% to 63%, indicating a non-trivial false-positive burden at the evaluated operating point.