Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients…

Cohort studyOphthalmic research· 2021

Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients with Diabetic Macular Edema.

Nardine Sharef, Rabea Kassem, Idan Hecht … Asaf Achiron

RetinaCohort studyPrognosis

Patients without baseline IZ/EZ defects have better visual acuity in diabetic macular edema.

Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients with Diabetic Macular Edema.

Nardine Sharef … Asaf Achiron

Ophthalmic research · 2021

Background

We have recently shown that defects in interdigitation and ellipsoid zones (IZ and EZ) can predict response to anti-VEGF therapy in a small group of treatment-naive diabetic macular edema (diabetic macular edema) patients.

Purpose

The aim of the current study is to further evaluate this association in a larger study group of patients over a longer follow-up time.

Methods

Thirty eyes of 30 treatment-naive diabetic macular edema patients were analyzed in this retrospective study.

n = Thirty eyes of 30 treatment-naive

20/36 vs. 20/70

Results

20/36 vs. 20/70

visual acuity was better for patients without baseline IZ/EZ defects

n = Thirty eyes of 30 treatment-naive

More results

The mean patients' age at baseline was 63.0 ± 10.0 years.

Patients underwent 3.9 ± 2.9 anti-VEGF injections for a mean of 9.1 ± 4.8 months.

BCVA gain correlated with IZ/EZ defect size reduction (r = 0.41, p = 0.02) but not with improvement in central macular thickness (r = 0.28, p = 0.121).

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Conclusion · 1 of 2

IZ/EZ defect size correlated not only with baseline BCVA but also predicted the change in BCVA after anti-VEGF treatment.

Conclusion · 2 of 2

Possible future automatic measurement of IZ/EZ defect size might prove helpful for the evaluation of treatment response.

Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients with Diabetic Macular Edema.

Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients with Diabetic Macular Edema.

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