Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in…

Cohort studyInternational journal of radiation oncology, biology, physics· May 2026

Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma Trial.

Orly Yariv, Hannah Williams, Karyn A Goodman … Abraham J Wu

Colon & Rectal SurgeryCohort studyTreatmentQ1IF 3.8

Higher-dose radiation boost was not associated with better organ preservation rates

Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma Trial.

Orly Yariv … Abraham J Wu

International journal of radiation oncology, biology, physics · May 2026

Purpose

We aimed to determine whether a higher radiation boost dose was associated with the probability of clinical complete response and organ preservation.

Methods

With clinical stage II/III rectal adenocarcinoma were randomized to induction chemotherapy followed by chemoradiation or chemoradiation followed by consolidation chemotherapy.

n = 324 patients

Results

organ preservation held steady regardless of boost dose, higher dose gave no added benefit

SD (3- and 5-yr OP)

52%

HD 3-yr OP

47%

HD 5-yr OP

45%

More results

Of the 324 patients randomized in the Organ Preservation in Patients with Rectal Adenocarcinoma trial, 303 patients were eligible for the present analysis, including 93 patients in the SD boost group (median total dose, 5000 cGy) and 210 in the HD boost group (median total dose, 5400 cGy).

More results

Clinical T3/T4 stage at presentation was more common among HD patients (83% and 10%, respectively) compared with SD patients (62% and 18%, respectively) (P < .001); otherwise, the 2 groups were comparable in all other measured aspects.

“

Conclusion

In the prospective phase 2 Organ Preservation in Patients with Rectal Adenocarcinoma trial of total neoadjuvant therapy for locally advanced rectal cancer, a higher radiation boost dose was not significantly associated with the probability of achieving a clinical complete response or the durability of organ preservation.

Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma Trial.

Does Radiation Boost Dose Affect Organ Preservation Rates? A Secondary Analysis of the Organ Preservation in Patients With Rectal Adenocarcinoma Trial.

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