Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in…

Cohort studyAge and ageing· Jul 2026

Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.

Masafumi Nozoe, Tatsuro Inoue, Masato Ogawa … Takeshi Morimoto

GeriatricsCohort studyPrognosisQ1IF 6.0

Stroke patients with all three geriatric conditions had higher risk of death, cardiovascular events

Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.

Masafumi Nozoe … Takeshi Morimoto

Age and ageing · Jul 2026 · Q1 in General Medicine

Purpose

This study aimed to explore the prevalence of these overlapping premorbid geriatric conditions and examine the association between the number of these conditions and the risk of mortality and major cardiovascular events within 1 year after acute stroke.

Methods

Were categorised according to the number of overlapping conditions (number of overlapping conditions), ranging from 0 to 3.

n = 781 patients

Results

having all three raises risk of death or cardiovascular events over fivefold

HR 5.20 (95% CI 2.77 to 9.73)

CI excludes the null - significant

More results

Among 781 patients (mean age 77.9 ± 12.6 years; 390 [49.9%] female), 226 patients (28.9%) were number of overlapping conditions 0, 289 (37.0%) were number of overlapping conditions 1, 161 (20.6%) were number of overlapping conditions 2 and 105 (13.4%) were number of overlapping conditions 3.

“

Conclusion

One-third of patients with acute stroke had overlapping premorbid geriatric conditions. The number of overlapping conditions was significantly associated with a composite event in a dose-response manner.

Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.

Overlapping premorbid frailty, multimorbidity and malnutrition and their associations with poor outcomes in patients with stroke.

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