Autologous Nanofat Indications in Wound Healing: A Systematic Review.
Autologous nanofat linked to accelerated wound healing in all studies measuring it.
Autologous Nanofat Indications in Wound Healing: A Systematic Review.
Chronic wounds and pathologic scars remain a persistent challenge in plastic surgery.
Imaging modalities (e.g., 3D imaging, ultrasound, angiography, digital analysis) were used in 23% (n = 5), each confirming structural or physiologic improvement.
A comprehensive PubMed search with no date restrictions was conducted in January 2026 using MeSH terms and keywords related to nanofat and wound-healing applications.
The search identified 53 records, of which 22 studies met the inclusion criteria after screening.
These included 20 human and two animal studies spanning randomized controlled trials (n = 3), prospective trials (n = 6), retrospective analyses (n = 6), case series (n = 4), and case reports (n = 3).
Mechanical emulsification was the predominant autologous nanofat preparation method (91%), often combined with filtration or centrifugation.
Treatment was well tolerated, with 77% of studies (n = 17) reporting minimal or no complications and only transient mild adverse effects, including mild pain, bruising, erythema, and edema.
Current evidence suggests that autologous nanofat is a promising regenerative therapy for wound healing and scar modulation.
Across diverse clinical applications, nanofat has been associated with improved tissue quality, enhanced healing, and favorable patient-reported outcomes, with minimal complications.
The mechanical processing of autologous tissue may also involve fewer regulatory concerns compared with more extensively manipulated cellular products.