Prevalence of Cerebral Abnormalities in Children With Congenital Heart Disease: A Systematic Review and Meta-Analysis.
Structural brain abnormalities found on magnetic resonance imaging in half of children after congenital heart disease surgery.
Prevalence of Cerebral Abnormalities in Children With Congenital Heart Disease: A Systematic Review and Meta-Analysis.
Children with congenital heart disease (congenital heart disease) are at risk of cerebral abnormalities.
Conduct a systematic review and meta-analysis to determine the prevalence of structural cerebral abnormalities on magnetic resonance imaging (magnetic resonance imaging) in children with congenital heart disease during prenatal, postnatal-preoperative, and postoperative periods.
Current evidence is limited by small sample sizes, single-center cohorts, and single time points.
half of children had brain abnormalities after heart surgery
Overall, 125 studies met the inclusion criteria.
Sample size included 521, 1895, and 2443 fetuses and children with congenital heart disease for prenatal, postnatal-preoperative, and postoperative analyses, respectively, ensuring sample independence.
LIMITATIONS: Variations in magnetic resonance imaging strength, postnatal vs fetal magnetic resonance imaging detection capacity, and the underlying rationale for neuroimaging.
Structural cerebral abnormalities are prevalent in a considerable number of fetuses and children with congenital heart disease.
A further increase is evident postoperatively, indicating the potential adverse impact of surgical intervention and postoperative care on brain outcomes.