Ablative Radioembolization Dosing Thresholds for Glass Microspheres Predictive of Complete Imaging Response…

Cohort studyJournal of vascular and interventional radiology : JVIR· Jul 2026

Ablative Radioembolization Dosing Thresholds for Glass Microspheres Predictive of Complete Imaging Response and Survival in Patients with Hepatocellular Carcinomas Larger than 4 cm: A Multi-institution Retrospective Analysis.

Kurt T Pianka, Breanna M Collins, Sarah Placek … Zachary T Berman

TheranosticsCohort studyPrognosisQ1IF 1.9

Higher D95 radiation dose linked to complete imaging response in hepatocellular carcinoma.

Ablative Radioembolization Dosing Thresholds for Glass Microspheres Predictive of Complete Imaging Response and Survival in Patients with Hepatocellular Carcinomas Larger than 4 cm: A Multi-institution Retrospective Analysis.

Kurt T Pianka … Zachary T Berman

Journal of vascular and interventional radiology · Jul 2026 · Q1 in Radiology

Purpose

To evaluate complete imaging response (CR) as a biomarker for survival and compare dosimetry models that predict CR in hepatocellular carcinomas (hepatocellular carcinomas) ≥ 4 cm treated with glass microsphere transarterial radioembolization (transarterial radioembolization).

Methods

This retrospective multicenter analysis included 112 consecutive patients who underwent transarterial radioembolization for untreated hepatocellular carcinomas ≥ 4 cm between June 2018 and June 2024.

n = 112 consecutive patients

Results

higher dose to 95% of the tumor predicted complete imaging response

482Gy

CR (D95)

213Gy

No CR (D95)

More results

Fifty-eight patients (51.8%) had CR 3 months after transarterial radioembolization.

CR was associated with improved overall survival (OS).

Multiple dose thresholds were correlated with CR and OS including D95.

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Conclusion · 1 of 2

For hepatocellular carcinomas > 4 cm, CR at 3 months was correlated with OS.

Conclusion · 2 of 2

Higher single-compartment dose thresholds or voxel-based dosimetry thresholds than currently recommended may better predict CR in hepatocellular carcinomas tumors ≥ 4 cm treated with glass microsphere transarterial radioembolization.

Ablative Radioembolization Dosing Thresholds for Glass Microspheres Predictive of Complete Imaging Response and Survival in Patients with Hepatocellular Carcinomas Larger than 4 cm: A Multi-institution Retrospective Analysis.

Ablative Radioembolization Dosing Thresholds for Glass Microspheres Predictive of Complete Imaging Response and Survival in Patients with Hepatocellular Carcinomas Larger than 4 cm: A Multi-institution Retrospective Analysis.

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