SPIO-induced susceptibility effects on quantitative liver MRI: cross-method assessment of R2*, PDFF, T1 mapping, and MRE.
Hepatic R2* rises roughly 3.5-fold after superparamagnetic iron oxide contrast administration on liver MRI.
SPIO-induced susceptibility effects on quantitative liver MRI: cross-method assessment of R2*, PDFF, T1 mapping, and MRE.
To compare hepatic and splenic transverse relaxivity (R2*) derived from two-dimensional (2D) and three-dimensional (3D) multi-echo gradient-echo (multi-echo gradient-echo) acquisitions before and after superparamagnetic iron oxide (superparamagnetic iron oxide) administration and to evaluate the effects of superparamagnetic iron oxide on proton density fat fraction (proton density fat fraction), MR spectroscopy (MR spectroscopy)-derived proton density fat fraction, native T1 mapping, and magnetic resonance elastography (magnetic resonance elastography)-derived liver stiffness.
In this retrospective study, 48 adults underwent liver MRI at 3 T before and after superparamagnetic iron oxide administration.
Superparamagnetic iron oxide markedly raises hepatic iron sensitive signal loss, reflecting strong liver uptake
Correlation between LiverLab and MRQuantif R2* measurements remained strong; however, inter-method agreement deteriorated at higher R2* values after superparamagnetic iron oxide administration.
Multi-echo gradient-echo-based proton density fat fraction measurements remained stable with preserved inter-method agreement.
Native hepatic T1 values decreased uniformly by approximately 500 ms following superparamagnetic iron oxide administration.
Magnetic resonance elastography-derived liver stiffness showed no significant change after superparamagnetic iron oxide administration.
Using superparamagnetic iron oxide as a controlled in vivo susceptibility model, this study provides an integrated evaluation of the susceptibility dependence of commonly used quantitative liver MRI biomarkers.
superparamagnetic iron oxide-induced susceptibility effects substantially increase hepatic R2*, impair the reliability of MR spectroscopy-based fat quantification, and markedly shorten native variable flip angle T1 measurements, while preserving the relative stability of multi-echo gradient-echo-based proton density fat fraction and magnetic resonance elastography-derived liver stiffness.