A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory…

Cohort studyJHLT open· Nov 2026

A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.

Mark Petrovic, Christian Eidson, Chen Chia Wang … Brian Lima

Transplant & Mechanical SupportCohort studyPrognosisQ3IF 1.3

CPOi adjusted for vasoactive-inotropic score best predicted postoperative complications after heart transplant

A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.

Mark Petrovic … Brian Lima

JHLT open · Nov 2026 · Q3 in Respiratory Medicine

Background

Cardiac power output index (CPOi) has emerged as a prognostic marker after heart transplantation (heart transplantation), yet its application to donation after circulatory death (DCD) hearts remains unstudied.

Methods

This is a single-center retrospective study of adult heart transplants (2020-2025), excluding multiorgan transplants, congenital heart disease, and patients requiring VA-ECMO within 72 h.

n = 500 patients

Results

AUC 0.729-0.752

CPOi adjusted for VIS predicted complications well, 1.0 would be perfect

n = 500 patients

More results

Among 500 patients (315 DBD, 185 DCD), hemodynamic trajectories did not differ across all metrics and timepoints.

Optimal ROC thresholds demonstrated negative predictive values of 83-89%.

After adjustment for recipient creatinine, hypertension, and ischemic time, donor type had no effect on any hemodynamic parameter.

More results

The composite endpoint occurred in 27.6% of DCD versus 23.2% of DBD recipients (p = 0.285).

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Conclusion · 1 of 2

Among heart transplantation recipients who did not require early mechanical circulatory support, early allograft function did not differ significantly between DBD and DCD recipients.

Conclusion · 2 of 2

CPOi VIS outperformed CPOi as a screening metric for morbidity and mortality, with thresholds applicable regardless of donor type.

A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.

A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.

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