Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for…

Cohort studyClinical research in cardiology : official journal of the German Cardiac Society· Aug 2026

Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for severe aortic stenosis.

Kornelia Löw, Nike Knufinke, Julius Steffen … Simon Deseive

Adult Cardiac SurgeryCohort studyPrognosisQ1IF 3.5

11% of transcatheter aortic valve replacement patients developed new mitral or tricuspid regurgitation.

Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for severe aortic stenosis.

Kornelia Löw … Simon Deseive

Clinical research in cardiology · Aug 2026 · Q1 in General Medicine

Background

Concomitant mitral (mitral) and/or tricuspid regurgitation (tricuspid regurgitation) in patients with aortic stenosis (aortic stenosis) is often regarded as a late-stage disease manifestation, resulting from left ventricular damage, pulmonary hypertension, and right heart dysfunction.

Purpose

The aim of this study was to characterize patients who develop atrioventricular valve regurgitation after transcatheter aortic valve replacement (transcatheter aortic valve replacement) and its impact on mortality.

Methods

We analyzed patients with severe aortic stenosis but without concomitant atrioventricular valve disease undergoing transcatheter aortic valve replacement between January 2016 and December 2021.

n = 114 patients

Results

new valve leakage after treatment, tied to worse survival

17patien

Combined MR and TR

75patien

Isolated MR

22patien

Isolated TR

More results

Among them, 17 patients experienced combined mitral and tricuspid regurgitation, 75 patients had isolated mitral, and 22 patients had isolated tricuspid regurgitation.

More results

The development of atrioventricular valve regurgitation after transcatheter aortic valve replacement was associated with significantly increased 3-year all-cause (p < 0.01) and cardiovascular mortality (p < 0.001).

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Conclusion · 1 of 2

In patients with severe aortic stenosis but without concomitant atrioventricular valve disease at baseline, a relevant proportion of patients developed mitral and/or tricuspid regurgitation after transcatheter aortic valve replacement despite the relief of outflow obstruction.

Conclusion · 2 of 2

Moreover, patients with new-onset atrioventricular valve regurgitation had a significantly higher 3-year all-cause and cardiovascular mortality.

Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for severe aortic stenosis.

Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for severe aortic stenosis.

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