Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the…

Cohort studyAnnals of medicine and surgery (2012)· Aug 2026

Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the esophagogastric junction: a cohort study of 156 cases.

Xiaofeng Duan, Haochen Wang, Yuxuan Zhang … Hongjing Jiang

Esophageal SurgeryCohort studyTreatment

Neoadjuvant therapy linked to better 2-year survival in esophagogastric junction cancer

Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the esophagogastric junction: a cohort study of 156 cases.

Xiaofeng Duan … Hongjing Jiang

Annals of medicine and surgery (2012) · Aug 2026

Background

To compare the efficacy and safety of neoadjuvant therapy (neoadjuvant therapy) followed by robot-assisted Ivor-Lewis esophagectomy vs. upfront surgery (S) in patients with locally advanced adenocarcinoma of the esophagogastric junction (AEG).

Methods

We retrospectively analyzed 156 patients with locally advanced AEG (cT2-4a/N0-2) who underwent robot-assisted Ivor-Lewis surgery with intrathoracic anastomosis between 2017 and 2024.

n = 156 patients

Results

neoadjuvant patients were far more likely to be alive at 2 years

NT 2-yr OS

87.5%

Surgery 2-yr OS

71%

More results

Of the 156 patients, 41 (26.3%) received neoadjuvant therapy.

“

Conclusion · 1 of 2

Neoadjuvant therapy significantly improves pathological responses and survival in advanced AEG without increasing surgical risks. The robotic-assisted approach enables the safe implementation of this multimodal treatment strategy.

Conclusion · 2 of 2

VISUAL ABSTRACT: http://links.lww.com/MS9/B274.

Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the esophagogastric junction: a cohort study of 156 cases.

Robot-assisted Ivor-Lewis esophagectomy with intrathoracic anastomosis for adenocarcinoma of the esophagogastric junction: a cohort study of 156 cases.

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