Combined Red Cell Exchange and Plasma Exchange for Post-Arrest Refractory Cardiorespiratory Failure in Sickle Cell Disease Sparing Extracorporeal Membrane Oxygenation.

Extracorporeal membrane oxygenation (extracorporeal membrane oxygenation) is increasingly utilized for refractory respiratory failure in sickle cell disease (sickle cell disease), yet registry data indicate in-hospital survival of only 40% in adults, with particular concerns regarding hemolysis, thrombosis, and bleeding processes already pathologically amplified in sickle cell disease.

Vasopressor requirements decreased within 24 h, with complete independence by day 8.

Inflammatory markers declined substantially within 72 h.

The patient was extubated on day 10 and discharged from the intensive care unit on day 14 without neurological deficit.