Patient-Reported Quality of Life in Lung Transplantation: Prospective Cohort Study.
Health perceptions improved earliest and most after lung transplantation
Patient-Reported Quality of Life in Lung Transplantation: Prospective Cohort Study.
Lung transplantation (lung transplantation) is an established treatment for patients with end-stage lung diseases and can substantially improve survival.
This study aimed to assess quality of life and track its longitudinal changes in patients who underwent lung transplantation using a disease-specific patient-reported outcome instrument.
This single-center prospective cohort study screened 66 patients for enrollment who underwent lung transplantation at the Xi'an Jiaotong University Lung Transplantation Center in China from June 2023 to December 2025.
health self-ratings rose most and soonest after transplant, signaling better perceived wellbeing
Linear mixed models analysis revealed significant overall time effects in 6 of 7 domains (likelihood ratio test: P<.01 in all cases).
Global well-being was the only domain with a positive trajectory (MD 1.18 at month 6; β=0.13 per month; P=.002), with significant improvement already evident at month 1 (MD 0.71; P=.23).
Lung transplantation significantly improved quality of life in patients with end-stage lung diseases, with the most substantial gains in health perceptions and respiratory symptoms.
Patient-reported outcome-based monitoring can capture clinically meaningful quality of life changes and should be integrated into routine posttransplant care to identify critical intervention time points and optimize long-term recovery.