Predictive performance of the Modified Frailty Index and ASA-PS classification for 30-day mortality after esophagectomy in patients with esophageal cancer.

Although American Society of Anesthesiologists Physical Status classification was independently associated with 30-day mortality, both American Society of Anesthesiologists Physical Status and mFI-5 demonstrated limited predictive performance following esophagectomy.

These findings suggest that mFI-5 and American Society of Anesthesiologists Physical Status alone provide limited discrimination for predicting 30-day mortality and support the development of esophagectomy-specific risk prediction models incorporating objective clinical, physiological, functional, and procedure-specific variables.