Specificity of Celbrea, a novel noninvasive thermal screening device, in women with recent negative…

Cohort studyFrontiers in oncology· 2026

Specificity of Celbrea, a novel noninvasive thermal screening device, in women with recent negative screening mammograms.

Nickolas Stabellini, Ashley Hendrix, Lisa McKnight … Alberto J Montero

Breast ImagingCohort studyDiagnosisQ2IF 3.1

Celbrea thermal scans correctly agreed with negative mammograms in most women

Specificity of Celbrea, a novel noninvasive thermal screening device, in women with recent negative screening mammograms.

Nickolas Stabellini … Alberto J Montero

Frontiers in oncology · 2026

Background

Breast cancer screening through mammography (mammography) remains the gold standard for early detection.

Purpose

This study evaluated whether negative results from Celbrea, a novel thermal-based device, were in agreement with negative mammography findings.

Methods

Were screened with Celbrea, an FDA-cleared thermal device for breast disease detection.

n = 5 women

Results

thermal scans matched negative mammograms in most women, though some false alarms occurred

Specificity 90.30 (95% CI 80.10 to 96.40)

null 0

80.10

96.40

CI excludes the null - significant

More results

non-significant (temperature differential ≤2°F) or significant.

Of 77 enrolled women, 68 had conclusive results for Celbrea.

Among these, 56 had negative results on both tests, 1 had a positive mammography (BI-RADS 3) with a non-significant Celbrea result, and 6 had negative mammography with significant Celbrea findings.

More results

Among women with heterogeneously or extremely dense breasts (n=28), specificity was 96.4% (95% CI: 81.7-99.9) and negative predictive value was 100.0% (95% CI: 87.2-100.0).

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Conclusion

Celbrea showed concordance of negative results with mammography. These findings demonstrate good discriminatory capacity and suggest potential clinical utility as an adjunctive or triage tool.

Specificity of Celbrea, a novel noninvasive thermal screening device, in women with recent negative screening mammograms.

Specificity of Celbrea, a novel noninvasive thermal screening device, in women with recent negative screening mammograms.

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