Prediction of anastomotic leakage after esophagectomy for esophageal cancer: a nomogram study integrating systemic inflammation indices and clinical factors.

Seven significant predictors of anastomotic leakage were identified in the training set: age, neoadjuvant radiotherapy, C-reactive protein-albumin-lymphocyte (CALLY) index, hypertension, neutrophil-to-lymphocyte ratio (neutrophil-to-lymphocyte ratio), neutrophil-to-monocyte ratio (neutrophil-to-monocyte ratio), and platelet-to-lymphocyte ratio (platelet-to-lymphocyte ratio).

The validation cohort demonstrated moderate predictive accuracy (AUC = 0.763), with consistent net benefits observed across different risk thresholds in decision curve analysis.