Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the…

AI / informaticsHeart (British Cardiac Society)· Aug 2026

Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the National Transcatheter Valve Therapeutics Registry.

Nanchao Hong, Lili Chen, Xian-Bao Liu … Junbo Ge

Adult Cardiac SurgeryAI / informaticsPrognosisQ1IF 2.8

Ascending aortic diameter above 41.6 mm predicts higher 30-day mortality after valve replacement.

Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the National Transcatheter Valve Therapeutics Registry.

Nanchao Hong … Junbo Ge

Heart (British Cardiac Society) · Aug 2026

Background

Data regarding the association between self-expandable transfemoral transcatheter aortic valve replacement (transfemoral transcatheter aortic valve replacement) and pure native aortic regurgitation (pure native aortic regurgitation) are limited.

Methods

With pure native aortic regurgitation were enrolled from the NTCVR in China between January 2017 and December 2023.

n = 890 patients

Results

aortas wider than 41.6 mm carry over 5-fold higher 30-day death risk

OR 5.03 (95% CI 2.04 to 12.70)

null 1

2.04

12.70

CI excludes the null - significant

More results

The in-hospital and 30-day all-cause mortality were 2.0% and 2.7%, respectively.

By multivariate logistic regression analysis, the diameter of the ascending aorta (OR, 1.103 (95% CI 1.005 to 1.212); p=0.039) and renal insufficiency (OR, 4.602 (95% CI 1.455 to 14.553); p=0.009) were associated with the 30-day all-cause mortality.

More results

Moreover, the NYHA class III/IV and annulus long diameter were predictors of technical success in multivariate analysis.

“

Conclusion · 1 of 2

In this large national registry-based observational and exploratory study, we identified the ascending aorta as the key predictor for pure native aortic regurgitation patients who underwent self-expandable transfemoral transcatheter aortic valve replacement.

Conclusion · 2 of 2

Patients with ascending aortic diameters greater than 41.6 mm may have a significantly higher 30-day all-cause mortality rate.

Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the National Transcatheter Valve Therapeutics Registry.

Ascending aorta and pure aortic regurgitation transcatheter aortic valve replacement: insights from the National Transcatheter Valve Therapeutics Registry.

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