Clinicopathologic Analysis of Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells.
Malignant mononuclear tumor cells show far higher proliferation than giant cells
Clinicopathologic Analysis of Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells.
To investigate the clinicopathological features, differential diagnosis, and prognosis of undifferentiated carcinoma of the pancreas with osteoclastic giant cells (UCOGCP).
The clinical histomorphological features and immunohistochemical results of 20 patients of UCOGCP were collected and analyzed.
most malignant cells were actively dividing, far more than the giant cells
The 20 patients ranged in age from 52 to 84 years, with a mean age of 62.8 years.
The cohort included 12 male patients and 8 female patients.
Of the 20 specimens, 9 were pancreaticoduodenectomy specimens, 7 were distal pancreatectomy specimens, and 4 were pancreatic puncture biopsy specimens.
Multinucleated giant cells expressed CD68, leukocyte common antigen (LCA/C45), and MAC387 and showed a low Ki-67 proliferation index (<10%).
Undifferentiated carcinoma of the pancreas with osteoclastic giant cell is a rare clinical entity with histomorphological features resembling those of malignant giant cell tumors of bone and soft tissue.
It can be distinguished from pleomorphic giant cell carcinoma and pancreatic adenosarcoma through immunohistochemistry and molecular testing. Radical surgical resection remains the optimal treatment for patients with UCOGCP.