Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience.

Cohort studyThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology· Aug 2025

Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience.

Merve Erkoç, Çiğdem Erhan, Leyla Çevirme … Güzin Özden

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Colon & Rectal SurgeryCohort studyDiagnosisQ3IF 1.9

Chronic diarrhea occurred in nearly half of patients with primary immunodeficiency.

Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience.

Merve Erkoç … Güzin Özden

The Turkish journal of gastroenterology · Aug 2025 · Q3 in Gastroenterology

Background

The aim was to determine the findings of the gastrointestinal system, which is the second most frequently affected system in the primary immunodeficiency (primary immunodeficiency) patient population, and the frequency of these findings.

Methods

Fifty patients with primary immunodeficiency were included in this study, and the characteristics of the patients, upper gastrointesti nal endoscopy, colonoscopy, and biopsy (endoscopic and colonoscopic) results were evaluated.

n = 23 patients

Results

48%

Chronic diarrhea was present in 48% of primary immunodeficiency patients studied.

n = 23 patients

More results

The median age of patients included in the study was 31 years (range 18-72 years) and 64% were male.

Seventy-two percentnof the patients had common variable immunodeficiency (common variable immunodeficiency) and 68% were diagnosed in adulthood.

Switched memory B cells were lower in chronic diarrhea (P = .003).

More results

Twenty-nine patients underwent upper gastrointestinal endoscopy, and the most common macroscopic findings were gastropathy (79.3%), duodenopathy (37.9%), and esophagitis (27.6%).

“

Conclusion · 1 of 3

In conclusion, chronic diarrhea is more common in primary immunodeficiency than in the general population, and switched memory B cells arenlower in primary immunodeficiency patients with chronic diarrhea.

Conclusion · 2 of 3

Most importantly, a collaboration between immunologists, gastroenterologists, and patholo gists is required when evaluating the gastrointestinal tract in primary immunodeficiency. Cite this article as: Erkoç M, Erhan Ç, Çevirme L, et al.

Conclusion · 3 of 3

Gastrointestinal tract findings in patients with primary immunodeficiency: A single-center 6-year experience. Turk J Gastroenterol. 2026;37(1):55-61.

Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience.

Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience.

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