Subphenotypes of pneumonia defined by pulmonary histopathological features.

By illuminating a spectrum of histopathologies and discriminating discrete subphenotypes of pneumonia, these studies provide a framework that may prove useful for developing and testing host-directed therapies for subsets of pneumonia patients.

At a Glance CommentaryScientific Knowledge on the Subject: Distinguishing subphenotypes of critical illnesses including pneumonia, ARDS, and sepsis is being pursued as a promising step towards optimizing application of host-directed therapies.