Cefdinir-Ornidazole for Bowel Preparation Before Colorectal Surgery: A Retrospective Cohort Study.
Adding oral cefdinir-ornidazole to bowel prep linked to lower surgical site infection odds
Cefdinir-Ornidazole for Bowel Preparation Before Colorectal Surgery: A Retrospective Cohort Study.
Mechanical bowel preparation (mechanical bowel preparation) combined with oral antibiotics (oral antibiotics) before colorectal surgery was significantly associated with reduced surgical site infection (surgical site infection) rates.
This study aimed to investigate whether mechanical bowel preparation combined with oral cefdinir and ornidazole was associated with lower surgical site infection rates.
Were stratified into two groups based on their preoperative bowel preparation regimen: mechanical bowel preparation alone versus mechanical bowel preparation combined with oral antibiotics (mechanical bowel preparation+oral antibiotics).
cefdinir plus ornidazole cut surgical site infection odds by nearly two thirds
After propensity score matching (78 patients per group), the mechanical bowel preparation+oral antibiotics group demonstrated significantly lower rates of surgical site infection (1.3% versus 12.8%, P = 0.016) and incisional infection (0% versus 9.0%, P = 0.023).
No significant differences were observed in other complications or the postoperative length of hospital stay.
Mechanical bowel preparation combined with oral cefdinir and ornidazole before colorectal surgery is associated with significantly lower surgical site infection rates.
However, it remains imperative that large-scale prospective studies be conducted to validate its safety profile.