HPV16/18 Genotyping Combined With PAX1 Methylation Triage Reduces Immediate Colposcopy While Improving CIN3+… | ScholarDeck

Paper

HPV16/18 Genotyping Combined With PAX1 Methylation Triage Reduces Immediate Colposcopy While Improving CIN3+ Detection: A Real-World Study of 3,233 Chinese Women.

New research · Pathology

Cancer control : journal of the Moffitt Cancer Center · 3w

Cohort studyCancer control : journal of the Moffitt Cancer Center· 2026

HPV16/18 Genotyping Combined With PAX1 Methylation Triage Reduces Immediate Colposcopy While Improving CIN3+ Detection: A Real-World Study of 3,233 Chinese Women.

Xing Fan, Haichun Guo, Sifeng Wang, Xiangwen Peng

Read paper

PathologyCohort studyDiagnosisQ1IF 3.0

HPV16/18 plus PAX1 methylation triage was linked to 46% fewer colposcopy referrals.

HPV16/18 Genotyping Combined With PAX1 Methylation Triage Reduces Immediate Colposcopy While Improving CIN3+ Detection: A Real-World Study of 3,233 Chinese Women.

Xing Fan … Xiangwen Peng

Cancer control · 2026 · Q1 in General Medicine

Background

Current cervical cancer screening guidelines recommend colposcopy referral for women co-positive for high-risk human papillomavirus (hrHPV) and abnormal cytology (≥ASC-US).

Methods

This was a retrospective cohort study.

n = 853 cases

Results

fewer patients sent for unnecessary colposcopy

Strategy A (PPV)

6.6%

Strategy B (PPV)

14.6%

More results

Non-16/18 hrHPV types (especially HPV52/58) accounted for over 30% of infections and 60% of CIN2+ lesions.

ConclusionA triage algorithm combining HPV16/18 genotyping with PAX1 methylation significantly enhances CIN3+ detection while substantially reducing immediate colposcopies.

“

Conclusion

This strategy is particularly well-suited for Chinese and other Asian populations where non-16/18 hrHPV types are prevalent, offering a more precise, cost-effective approach toward WHO's 2030 cervical cancer elimination goals.

Read paper