The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled…

Randomized trialHealth science reports· Jun 2026

The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled Double-Blind Clinical Trial.

Masoumeh Taghizadeh, Zahra Kourki Nejad Gharaee, Gholamreza Bazmandegan … Ali Mohammad Madahian

Colon & Rectal SurgeryRandomized trialTreatmentQ2IF 2.9

Ostrich oil reduced anal fissure pain more than glyceryl trinitrate over time

The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled Double-Blind Clinical Trial.

Masoumeh Taghizadeh … Ali Mohammad Madahian

Health science reports · Jun 2026 · Q2 in General Medicine

Background

An anal fissure is a tear in the anal canal below the dentate line, affecting one in five people at some point in their lives.

Purpose

This study aims to evaluate the effect of ostrich oil on pain reduction and healing in patients with chronic anal fissure (chronic anal fissure), with implications for improving home-based palliative care strategies.

Methods

In this clinical trial, 150 patients with chronic anal fissure were randomly divided into intervention and glyceryl trinitrate (glyceryl trinitrate) therapy groups.

n = 150 patients

F(3,444)=11.35

Results

F(3,444)=11.35

pain dropped faster with ostrich oil than glyceryl trinitrate as time went on

n = 150 patients

More results

Although ulcer grade and bleeding severity were similar immediately post-treatment, the ostrich oil group demonstrated superior long-term outcomes at 2- and 4-month follow-ups, including fewer Grade 3 ulcers, less bleeding, and lower recurrence rates (all p < 0.05).

More results

Ostrich oil thus provided more effective and sustained relief than glyceryl trinitrate for pain management and ulcer healing.

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Conclusion · 1 of 3

The results of this study suggest that ostrich oil may reduce pain, accelerate healing, shorten the treatment duration, and prevent recurrence of chronic anal fissure.

Conclusion · 2 of 3

Given its ease of application and favorable safety profile, ostrich oil could be considered a valuable component of home-based palliative care strategies for managing chronic anal fissure.

Conclusion · 3 of 3

Trial Registration: Iranian Registry of Clinical Trials (Iranian Registry of Clinical Trials): IRCT20190128042525N4.

The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled Double-Blind Clinical Trial.

The Effect of Ostrich Oil on Pain, Healing, and Recurrence of Chronic Anal Fissure: A Randomized Controlled Double-Blind Clinical Trial.

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