Evaluation of clinicopathological features of renal biopsies in non-lupus rheumatic diseases: a university hospital experience.
Amyloidosis was the most frequent renal biopsy finding in familial Mediterranean fever patients.
Evaluation of clinicopathological features of renal biopsies in non-lupus rheumatic diseases: a university hospital experience.
Renal involvement is a common condition in rheumatologic diseases.
The aim of this study was to evaluate the clinical presentations and histopathological results in patients diagnosed with non-lupus rheumatic diseases who underwent renal biopsy.
The records of 900 renal biopsies performed at our hospital between 2004 and 2023 were retrospectively reviewed, and 139 patients diagnosed with non-lupus rheumatic diseases were included.
amyloidosis was the diagnosis in most familial Mediterranean fever patients biopsied, far more than other causes
Among the patients, 46 had rheumatoid arthritis (rheumatoid arthritis), 31 had ankylosing spondylitis (ankylosing spondylitis), 31 had familial Mediterranean fever (familial Mediterranean fever), 17 had Behçet's disease (BD), and 14 had psoriasis (psoriasis).
The most common indication for biopsy was hematuria + subnephrotic proteinuria, accounting for 17.3%.
The most frequent pathological diagnosis was amyloidosis (36.7%), followed by focal segmental glomerulosclerosis (focal segmental glomerulosclerosis) (19.4%), chronic tubulointerstitial nephritis (tubulointerstitial nephritis) (8.6%), immunoglobulin A (IgA) nephropathy (7.9%), and membranous glomerulonephritis (7.2%).
Close monitoring of renal functions and performing biopsy when necessary are critically important in these patients.