Laparoscopic resection of metachronous metastasis to the contralateral adrenal gland 5 years after radical…

Case reportInternational journal of surgery case reports· Jun 2026

Laparoscopic resection of metachronous metastasis to the contralateral adrenal gland 5 years after radical nephrectomy.

Kenan Mohsen Sbh, Ahmad Al-Bitar, Abdul Ghani Alshalabi

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Robotic & Minimally Invasive SurgeryCase reportTreatmentQ3IF 0.6

Isolated contralateral adrenal metastasis after nephrectomy for renal cell carcinoma is exceptionally rare

Laparoscopic resection of metachronous metastasis to the contralateral adrenal gland 5 years after radical nephrectomy.

Kenan Mohsen Sbh … Abdul Ghani Alshalabi

International journal of surgery case reports · Jun 2026 · Q3 in Surgery

Background

Renal cell carcinoma (renal cell carcinoma), especially clear cell renal cell carcinoma (ccRCC), frequently metastasizes to the lungs and bones after nephrectomy.

≈0.7%

Results

≈0.7%

contralateral adrenal spread after nephrectomy is rare, most recurrences occur elsewhere

More results

CASE PRESENTATION: A 57-year-old male, 5 years after a left radical nephrectomy for stage I ccRCC, presented with mild right upper quadrant discomfort.

Ultrasound showed a 3.5-cm right adrenal mass with no significant internal vascularity on Doppler - an atypical hypovascular finding for ccRCC metastasis.

More results

Histopathology and immunohistochemistry (immunohistochemistry) (PAX-8+, CA-IX+, CD10+; Melan-A-, Inhibin-, Synaptophysin-) confirmed metastatic ccRCC.

Recovery was uneventful, with no recurrence observed on 2-year surveillance imaging.

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Conclusion · 1 of 2

ccRCC can present with late, solitary metastases to unusual sites like the contralateral adrenal gland years after initial treatment. A high index of suspicion and thorough pathological evaluation are essential.

Conclusion · 2 of 2

Minimally invasive surgical resection is effective for isolated metachronous metastases. This case report reinforces the need for long-term, vigilant follow-up of renal cell carcinoma survivors.

Laparoscopic resection of metachronous metastasis to the contralateral adrenal gland 5 years after radical nephrectomy.

Laparoscopic resection of metachronous metastasis to the contralateral adrenal gland 5 years after radical nephrectomy.

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