Impact of Pre-operative Single-dose Methylprednisolone on Outcomes After Major Hepatectomy in Adults: A…

Cohort studyJournal of clinical and experimental hepatology· 2026

Impact of Pre-operative Single-dose Methylprednisolone on Outcomes After Major Hepatectomy in Adults: A Prospective, Randomised Controlled Trial.

Muddada Vivekananda, Guhan Venkatakrishnan, Binoj S P Thankamony Amma … Sudhindran Surendran

Hepatobiliary & Pancreatic SurgeryCohort studyQ2IF 2.4

Preoperative single-dose steroid before major hepatectomy lowered postoperative day 5 c-reactive protein

Impact of Pre-operative Single-dose Methylprednisolone on Outcomes After Major Hepatectomy in Adults: A Prospective, Randomised Controlled Trial.

Muddada Vivekananda … Sudhindran Surendran

Journal of clinical and experimental hepatology · 2026

Background

The impact of a single preoperative steroid dose on inflammatory modulation and clinical outcomes in major hepatectomy remains uncertain.

Purpose

The aim of this study was to assess the influence of intraoperative administration of a single dose of steroids on postoperative morbidity and mortality in patients undergoing major hepatectomies.

Methods

In this investigator-blinded, randomised trial, 124 patients scheduled for major hepatectomy (including 79 living-donor hepatectomies and 60 minimally invasive procedures) were allocated to either the steroid-administered group (500 mg methylprednisolone administered intravenously at induction of anaesthesia) or the control group (no steroids).

n = 124 patients

Results

28

vs 58

less inflammation after surgery with steroids

n = 124 patients

More results

Both groups showed comparable rates of Pringle manoeuvre application (62% steroids vs 52% control) and duration (30 min each).

More results

The number of patients experiencing complications did not differ significantly between groups (12 [24%] steroids vs 18 [32%] control; P = 0.353) although the absolute number of Clavien-Dindo complications was significantly lower in the steroid-administered group (12 [26%] vs 26 [46.4%]; P = 0.03), recognising that individual patients could have multiple complications.

“

Conclusion

Administration of preoperative steroids during major hepatectomy attenuated the postoperative inflammatory response but did not significantly reduce overall postoperative complications.

Impact of Pre-operative Single-dose Methylprednisolone on Outcomes After Major Hepatectomy in Adults: A Prospective, Randomised Controlled Trial.

Impact of Pre-operative Single-dose Methylprednisolone on Outcomes After Major Hepatectomy in Adults: A Prospective, Randomised Controlled Trial.

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