Endocrine and neurological complications in total versus completion thyroidectomy: a systematic review and meta-analysis.
Total thyroidectomy raises transient hypocalcemia odds versus completion thyroidectomy
Endocrine and neurological complications in total versus completion thyroidectomy: a systematic review and meta-analysis.
The optimal extent of thyroidectomy remains controversial.
This meta-analysis and systematic review compared thyroidectomy and completion thyroidectomy using endocrine and neurological outcomes in the postoperative period.
We searched databases of PubMed, Scopus, Embase, Web of Science and Google Scholar in accordance with PRISMA and until September 1, 2025.
total thyroidectomy raises transient low calcium risk versus completion surgery
Forty-nine articles were incorporated.
Neurological, such as recurrent laryngeal nerve (recurrent laryngeal nerve) palsy (OR = 0.90; 95% CI: 0.671.21) and the recurrent laryngeal nerve injury (OR = 0.45; 95% CI: 0.151.05) showed no significant results between the two procedures.
These results were validated by sensitivity analyses on the consistency of the results across the study quality strata.
Thyroidectomy is linked to higher occurrence of transient endocrine complications but is equal to completion thyroidectomy regarding neurological safety.
These findings emphasize the role of personalized surgical decision-making, careful parathyroid conservation, and standardized perioperative care as ways of reducing the risk of complications and maximizing the outcome of thyroid surgery.
CLINICAL TRIAL NUMBER: Not applicable.