Evaluating diagnostic efficacy of multigene testing in non-diagnostic thyroid nodules by fine-needle aspiration cytology: A prospective cohort study.

Final histopathology identified 165 benign and 53 malignant nodules.

Molecular testing detected 10 distinct point mutations and seven gene fusions.

Among benign nodules, 147 tested negative and 18 tested positive, whereas 44 malignant nodules tested positive and nine tested negative.

The predictive model incorporated 18 clinical and 19 molecular features.