Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor…

Cohort studyCurrent therapeutic research, clinical and experimental· Dec 2026

Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study.

Tomohiro Shigematsu, Soichiro Tajima, Hiroshi Noguchi … Mayako Uchida

Transplant SurgeryCohort studyQ2IF 3.3

Perioperative daprodustat associated with lower rates of slow graft function after living donor kidney transplant

Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study.

Tomohiro Shigematsu … Mayako Uchida

Current therapeutic research, clinical and experimental · Dec 2026

Background

Hypoxia-inducible factor prolyl hydroxylase (hypoxia-inducible factor prolyl hydroxylase) inhibitors, such as daprodustat, have demonstrated nephroprotective effects in preclinical models.

Purpose

This study aimed to evaluate the effects of daprodustat on early posttransplant graft functions in living donor kidney transplantation.

Methods

Were divided into the daprodustat group, who received the drug from preoperative Day 1 to postoperative Day 7, and the control group, who did not receive hypoxia-inducible factor prolyl hydroxylase inhibitors during this period.

n = 32 patients

Results

slow graft function occurred only in the control group, none with daprodustat

0%

Daprodustat

12.5%

Control

More results

The daprodustat group exhibited better graft function, reflected by higher estimated glomerular filtration rates in the early posttransplant period (mean ± standard deviation: Week 1, 53.3 ± 16.1 vs control 41.9 ± 17.9 mL/min/1.73 m²; P = 0.001; Week 2, 55.3 ± 17.6 vs 46.0 ± 15.1; P = 0.008).

More results

No delayed graft function or thrombotic events occurred, and rejection did not differ between groups.

“

Conclusion

These findings raise the possibility that perioperative daprodustat use may be associated with improved early graft function in living donor kidney transplantation, warranting further investigation.

Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study.

Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study.

Related papers