Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.

Cohort studyNoro psikiyatri arsivi· 2026

Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.

Esra Taşkıran, Bilgin Öztürk, Naim Ata … Murat Kürtüncü

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NeuropathologyCohort studyDiagnosis

Brain biopsy is needed in only 0.02% of multiple sclerosis patients.

Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.

Esra Taşkıran … Murat Kürtüncü

Noro psikiyatri arsivi · 2026

Background

While tissue sampling through brain biopsy is rarely required throughout the Multiple sclerosis (multiple sclerosis) disease course, it remains essential in cases with atypical clinical or radiological findings where other diagnostic methods are inconclusive.

Purpose

This study aims to present brain biopsy findings in patients diagnosed with multiple sclerosis.

Methods

Multiple sclerosis patients were screened from the national database.

n = 21 patients

0.02%

Results

0.02%

brain biopsy is almost never needed to confirm multiple sclerosis

n = 21 patients

More results

Pathological findings revealed 12 malignant diagnoses, including lymphoma, glioblastoma, metastasis, and nine non-malignant conditions, such as vasculitis, demyelination, and benign masses.

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Conclusion

Brain biopsy is rarely required in patients with multiple sclerosis; however, it should be considered in cases of atypical lesion development, underscoring the need for meticulous clinical monitoring.

Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.

Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.

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