Quantifying Mast Cell and Eosinophil Cellular Density in Skin Biopsy Tissue From Adults With Maculopapular…

StudyThe American Journal of dermatopathology· Feb 2025

Quantifying Mast Cell and Eosinophil Cellular Density in Skin Biopsy Tissue From Adults With Maculopapular Cutaneous Mastocytosis as Compared With Urticaria and Normal Skin: A Retrospective Histopathologic Study.

Anne L King, Carmen M Montagnon, Austin Todd … Emma F Johnson

DermatopathologyStudyDiagnosisQ3IF 0.6

Mast cell density is far higher in mastocytosis than in urticaria or normal skin

Quantifying Mast Cell and Eosinophil Cellular Density in Skin Biopsy Tissue From Adults With Maculopapular Cutaneous Mastocytosis as Compared With Urticaria and Normal Skin: A Retrospective Histopathologic Study.

Anne L King … Emma F Johnson

The American Journal of dermatopathology · Feb 2025 · Q3 in Pathology

Background

Maculopapular cutaneous mastocytosis (maculopapular cutaneous mastocytosis) is a rare disorder characterized by a pathologic accumulation of mast cells in the skin, which may or may not be accompanied by systemic mastocytosis.

Methods

We identified adult patients diagnosed with maculopapular cutaneous mastocytosis and urticarial tissue reaction/chronic urticaria on skin biopsy and compared the mast cell and eosinophil counts per 1 mm 2 in 10 cases each of maculopapular cutaneous mastocytosis, chronic urticaria, and normal skin from routine biopsies.

n = 10 cases

177.3

Results

177.3

mast cells were far denser in mastocytosis than in urticaria or normal skin

n = 10 cases

More results

The calculated "cut point" for mastocytosis versus chronic urticaria and normal skin was 66 mast cells per 1 mm 2 , whereas the value for controls versus urticaria was 37 mast cells per 1 mm 2 .

More results

Eosinophils had similar density in maculopapular cutaneous mastocytosis and urticaria, and their presence was significant in the differentiation of maculopapular cutaneous mastocytosis and urticaria from normal tissue.

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Conclusion · 1 of 2

This study adds to the literature by providing objective mast cell density data to distinguish challenging cases of cutaneous mastocytosis from urticarial reactions and normal skin.

Conclusion · 2 of 2

Future studies could explore the development of computer-aided estimations of cellular density with more extensive comparison with other inflammatory conditions to translate our findings more readily into clinical practice.

Quantifying Mast Cell and Eosinophil Cellular Density in Skin Biopsy Tissue From Adults With Maculopapular Cutaneous Mastocytosis as Compared With Urticaria and Normal Skin: A Retrospective Histopathologic Study.

Quantifying Mast Cell and Eosinophil Cellular Density in Skin Biopsy Tissue From Adults With Maculopapular Cutaneous Mastocytosis as Compared With Urticaria and Normal Skin: A Retrospective Histopathologic Study.

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