Perioperative anesthetic considerations and outcomes in Crouzon syndrome: a retrospective analysis of Le Fort III advancement surgery.
Longer operative duration is associated with higher odds of postoperative complications.
Perioperative anesthetic considerations and outcomes in Crouzon syndrome: a retrospective analysis of Le Fort III advancement surgery.
Le Fort III osteotomy and advancement in children with Crouzon syndrome represents a crucial therapeutic modality for severe midface hypoplasia.
This study aims to summarize perioperative anesthetic management strategies, describe perioperative outcomes, and analyze risk factors for postoperative complications in this specific population.
Medical records of consecutive children with Crouzon syndrome undergoing Le Fort III osteotomy and advancement were retrospectively reviewed from Peking University International Hospital between December 2017 and January 2026.
each extra minute of surgery slightly raised complication risk
The median operative time was 215 minutes (IQR, 180-279 minutes), intraoperative blood loss was 14.3 mL/kg, and the allogeneic blood transfusion rate was 68.1%.
Postoperative complications occurred in 29.8% of patients (14/47).
Intraoperative fresh frozen plasma transfusion were not significant in the adjusted model.
Anesthetic management for Le Fort III osteotomy in children with Crouzon syndrome requires meticulous attention to difficult airway anatomy and significant intraoperative hemorrhage.
Prolonged operative duration significantly increase the risk of postoperative complications.
Future research should prioritize multicenter prospective cohort designs to establish larger, more comprehensive databases capable of validating the present findings.